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Genes and Proteins
Investigation 2
Investigation 2
Genes and Proteins

Phase 1 – Defined Understanding
Student Guide
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Access Teacher Guide
Student Guide with answers
Teacher PreLab
Prepare for the Experiment
Phase 2 – Dynamic Understanding
► Investigation Two Summary – Lab Goals
In Investigation Two, you analyzed how the sequence of the amino acids in a protein can affect the structure of the protein. During this Investigation, you:
1. Modeled a wild type protein and 4 mutations.
2. Observed the effects of the mutations on the protein structure and function.
3. Calculated the rate of water transfer using the following formula:
► Investigation Two Summary – Learning Goals
Through these experiments, you concluded that:
1. Mutations in DNA can lead to changes in the amino acid sequence of a protein. Changes in amino acid sequence can cause changes to protein structure. Changes in protein structure may cause changes in function. If a protein cannot function properly, some of the functions of the organism may be affected because the functions of an organism often depend on the functions of the proteins within the organism. However, not all mutations cause changes in an organism. Some mutations in DNA do not cause changes in the amino acid sequence of a protein and therefore do not change a protein’s structure or function. Some mutations in DNA cause changes in amino acid sequences without changing the structure and function of a protein. Some mutations cause changes in the structure of a protein without affecting the function of a protein.
Concept Slides
Launch and Discuss
Mathematics Concepts in This Investigation
- patterns/sequences
- grouping
- data table
- volume in mL and liters
- time in seconds
- calculate the rate of water transfer (ml/s)
- division
- calculate averages
- addition
- decimals to the nearest tenth
- greater than/less than/equal to
- problem-solving
- comparing values
- data analysis